2,3,4,5-Tetra-(4-Pyridyl) Thiophene

中文名	2,3,4,5-Tetra-(4-Pyridyl) Thiophene
英文名	2,3,4,5-Tetra-(4-Pyridyl) Thiophene
别名	2,3,4,5-四-(4-吡啶)噻吩 2,3,4,5-四(4-吡啶基)噻吩 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine 4,4?4乔,4乔?(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
英文别名	GANT58 Nsc75503 2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE 2,3,4,5-Tetra-(4-Pyridyl) Thiophene 1,2,3,4-Tetrakis(4-pyridyl)thiophene -(2,3,4,5-Thiophentetrayl)tetrakis-pyridine Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-
CAS	64048-12-0
EINECS	200-258-5
化学式	C24H16N4S
分子量	392.48
密度	1.254
熔点	252-253℃
沸点	414.1±40.0 °C(Predicted)
溶解度	DMSO: >10 mg/mL
酸度系数	4.50±0.10(Predicted)
存储条件	Keep in dark place,Sealed in dry,2-8°C
外观	黄色固体
颜色	white to pale yellow
体外研究	GANT58 is a downstream inhibitor of Hh signaling. GANT58 is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked. GANT58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway. GANT58 (NSC75503) has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species). GANT58 has been shown to inhibit GLI transactivation.
体内研究	Nude mice are injected s.c. with GLI1-positive 22Rv1 prostate cancer cells, and tumors are established (median size ≈250 mm 3 ). Nude mice are treated with daily s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). However, after 3 days, cyclopamine-treated animals presented with severe ulcerations at the injection sites. Therefore, changing the treatment regimen to injections only every second day. To be able to compare all compounds, this protocol is also introduced for the GANTs, although mice treated with these compounds showed no such signs of toxicity. All injections are done 2-3 cm away from the tumors. During an 18-day treatment period, suppression of tumor cell growth is observed for all compounds. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size.
WGK Germany	3
上游原料	1,2-二吡啶乙炔
下游产品	1,2-双(4-吡啶基)乙烷

2,3,4,5-Tetra-(4-Pyridyl) Thiophene - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.548 ml	12.74 ml	25.479 ml
5 mM	0.51 ml	2.548 ml	5.096 ml
10 mM	0.255 ml	1.274 ml	2.548 ml
5 mM	0.051 ml	0.255 ml	0.51 ml

最后更新：2024-01-02 23:10:35

2,3,4,5-Tetra-(4-Pyridyl) Thiophene - 简介

2,3,4,5-Tetra-(4-Pyridyl) Thiophene（简称TPT）是一种有机化合物。TPT具有许多有趣的性质和应用。

性质：
TPT是一种具有天然硫黄的杂环化合物。它具有黄色晶体，并且具有良好的溶解性，可在有机溶剂中溶解。TPT具有良好的热稳定性和光学性能，使其在化学领域中具有广泛的应用。

用途：
TPT在某些领域具有重要的应用价值。TPT可以作为一种有效的配体或中间体，用于合成新型的配位聚合物、金属有机骨架材料、光电材料和荧光探针等。其次，TPT可用于有机太阳能电池、发光二极管（LED）和有机场效应晶体管（OFET）等器件的制造。TPT还可以用于某些光敏材料、催化剂和有机光电元件等的制备。

制法：
TPT的制备方法有多种途径。一种常用的方法是通过4-吡啶硫酮和邻硝基甲苯反应，生成N-(2, 3, 4, 5-四吡啶基)硫酮，然后再通过催化加氢反应制备TPT。还可以通过其他方法，如催化醋酸钯、热溶法等进行合成。

安全信息： TPT是一种有机化合物，在操作时需要采取适当的防护措施，避免接触皮肤和眼睛。其次，TPT在高温下可能会发生分解，产生有毒气体，需要在通风良好的条件下操作。TPT需要储存在干燥、阴凉的地方，避免与氧气或水接触。对于TPT的具体安全性评估，应根据实际情况进行，参考相关的化学品安全说明书或咨询专业人员。

最后更新：2024-04-10 22:29:15

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产品名: 2,3,4,5-Tetra-(4-Pyridyl) Thiophene 去供应商网站查看询盘
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